Defective DNA Repair and Neurodegenerative Disease
نویسندگان
چکیده
منابع مشابه
Defective DNA Repair and Neurodegenerative Disease
Defects in cellular DNA repair processes have been linked to genome instability, heritable cancers, and premature aging syndromes. Yet defects in some repair processes manifest themselves primarily in neuronal tissues. This review focuses on studies defining the molecular defects associated with several human neurological disorders, particularly ataxia with oculomotor apraxia 1 (AOA1) and spino...
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Genomic instability is the driving force behind cancer development. Human syndromes with DNA repair deficiencies comprise unique opportunities to study the clinical consequences of faulty genome maintenance leading to premature aging and premature cancer development. These syndromes include chromosomal breakage syndromes with defects in DNA damage signal transduction and double-strand break rep...
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Oxidative DNA damage is one of the earliest detectable events in several neurodegenerative diseases, often preceding the onset of the clinical symptoms. Moreover, neurons in the adult human brain can re-enter the cell division cycle, likely allowing DNA repair. Impairments of DNA repair pathways are reported in neurons of patients suffering from one of several neurodegenative diseases and might...
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Damage to cellular DNA can result in the loss of genetic information, in cellcycle arrest or even in cell death. So DNA is constantly surveyed for the presence of lesions and appropriate responses are mounted: failure can lead to genomic instability, mutations and ultimately cancer. In the last few years, rapid progress has been made in understanding many aspects of DNA repair. For example, it ...
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Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), are becoming common in the world with increasing number of aged people in the population. Many investigations have been performed in an attempt to elucidate the mechanisms of neurodegenerative diseases. However, no single etiopathological factor was found to be responsible for s...
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ژورنال
عنوان ژورنال: Cell
سال: 2007
ISSN: 0092-8674
DOI: 10.1016/j.cell.2007.08.043